Decreased Contractile and Metabolic Reserve in Peroxisome Proliferator–Activated Receptor-α–Null Hearts Can Be Rescued by Increasing Glucose Transport and Utilization | Zendy

Ivan Luptak | Zendy; James A. Balschi | Zendy; Yanqiu Xing | Zendy; Teresa C. Leone | Zendy; Daniel P. Kelly | Zendy; Rong Tian | Zendy

Open Access

Decreased Contractile and Metabolic Reserve in Peroxisome Proliferator–Activated Receptor-α–Null Hearts Can Be Rescued by Increasing Glucose Transport and Utilization

Author(s) -

Ivan Luptak,

James A. Balschi,

Yanqiu Xing,

Teresa C. Leone,

Daniel P. Kelly,

Rong Tian

Publication year - 2005

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.105.534594

Subject(s) - medicine , endocrinology , peroxisome proliferator activated receptor , receptor , peroxisome , glucose uptake , insulin

Downregulation of peroxisome proliferator-activated receptor-alpha (PPARalpha) in hypertrophied and failing hearts leads to the reappearance of the fetal metabolic pattern, ie, decreased fatty acid oxidation and increased reliance on carbohydrates. Here, we sought to elucidate the functional significance of this shift in substrate preference.

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