Temporally Controlled Onset of Dilated Cardiomyopathy Through Disruption of the SRF Gene in Adult Heart | Zendy

Ara Parlakian | Zendy; Claude Charvet | Zendy; Brigitte Escoubet | Zendy; Mathias Mericskay | Zendy; Jeffery D. Molkentin | Zendy; Guillaume GaryBobo | Zendy; León J. De Windt | Zendy; MarieAline Ludosky | Zendy; Denise Paulin | Zendy; Dominique Daegelen | Zendy; David Tuil | Zendy; Zhenlin Li | Zendy

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Temporally Controlled Onset of Dilated Cardiomyopathy Through Disruption of the SRF Gene in Adult Heart

Author(s) -

Ara Parlakian,

Claude Charvet,

Brigitte Escoubet,

Mathias Mericskay,

Jeffery D. Molkentin,

Guillaume GaryBobo,

León J. De Windt,

MarieAline Ludosky,

Denise Paulin,

Dominique Daegelen,

David Tuil,

Zhenlin Li

Publication year - 2005

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.105.533778

Subject(s) - serum response factor , medicine , heart failure , dilated cardiomyopathy , cardiomyopathy , cardiac function curve , contractility , myocyte , endocrinology , gene expression , biology , gene , biochemistry

Serum response factor (SRF) is a cardiac transcription factor involved in cell growth and differentiation. We have shown, using the Cre/loxP system, that cardiac-specific disruption of SRF gene in the embryonic heart results in lethal cardiac defects. The role of SRF in adult heart is unknown.

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