Implantation of Mesenchymal Stem Cells Overexpressing Endothelial Nitric Oxide Synthase Improves Right Ventricular Impairments Caused by Pulmonary Hypertension | Zendy

Sachiko KankiHorimoto | Zendy; Hitoshi Horimoto | Zendy; Shigetoshi Mieno | Zendy; Kenji Kishida | Zendy; Fusao Watanabe | Zendy; Eisuke Furuya | Zendy; Takahiro Katsumata | Zendy

Open Access

Implantation of Mesenchymal Stem Cells Overexpressing Endothelial Nitric Oxide Synthase Improves Right Ventricular Impairments Caused by Pulmonary Hypertension

Author(s) -

Sachiko KankiHorimoto,

Hitoshi Horimoto,

Shigetoshi Mieno,

Kenji Kishida,

Fusao Watanabe,

Eisuke Furuya,

Takahiro Katsumata

Publication year - 2006

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.105.001487

Subject(s) - enos , medicine , mesenchymal stem cell , pulmonary hypertension , nitric oxide synthase , transplantation , nitric oxide , ventricular pressure , endocrinology , cardiology , pathology , hemodynamics

Pulmonary hypertension (PH) is a life-threatening disease. Bone marrow cell transplantation is reported to reduce the development of PH by increasing vascular beds in pulmonary circulation. However, adenoviral overexpression of endothelial nitric oxide synthase (eNOS) in the lung is also known to reduce PH. Because mesenchymal stem cells (MSCs) are potential cell sources for neovascularization, the implantation of MSCs overexpressing eNOS (MSCs/eNOS) may further improve the surgical results. We evaluated the efficacy of MSCs/eNOS implantation in monocrotaline (MCT)-induced PH rats.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research