Adenoviral Human BCL-2 Transgene Expression Attenuates Early Donor Cell Death After Cardiomyoblast Transplantation Into Ischemic Rat Hearts | Zendy

Ingo Kutschka | Zendy; Theo Kofidis | Zendy; Ian Y. Chen | Zendy; Georges von Degenfeld | Zendy; Monika Zwierzchoniewska | Zendy; Grant Hoyt | Zendy; Takayasu Arai | Zendy; Darren R. Lebl | Zendy; Stephen L. Hendry | Zendy; Ahmad Y. Sheikh | Zendy; David T. Cooke | Zendy; Andrew J. Connolly | Zendy; Helen M. Blau | Zendy; Sanjiv S. Gambhir | Zendy; Robert C. Robbins | Zendy

Open Access

Adenoviral Human BCL-2 Transgene Expression Attenuates Early Donor Cell Death After Cardiomyoblast Transplantation Into Ischemic Rat Hearts

Author(s) -

Ingo Kutschka,

Theo Kofidis,

Ian Y. Chen,

Georges von Degenfeld,

Monika Zwierzchoniewska,

Grant Hoyt,

Takayasu Arai,

Darren R. Lebl,

Stephen L. Hendry,

Ahmad Y. Sheikh,

David T. Cooke,

Andrew J. Connolly,

Helen M. Blau,

Sanjiv S. Gambhir,

Robert C. Robbins

Publication year - 2006

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.105.001370

Subject(s) - medicine , transplantation , bioluminescence imaging , ligation , ejection fraction , apoptosis , heart transplantation , myocardial infarction , genetic enhancement , cardiology , andrology , urology , pathology , luciferase , heart failure , biology , transfection , gene , biochemistry

Cell transplantation for myocardial repair is limited by early cell death. Gene therapy with human Bcl-2 (hBcl-2) has been shown to attenuate apoptosis in the experimental setting. Therefore, we studied the potential benefit of hBcl-2 transgene expression on the survival of cardiomyoblast grafts in ischemic rat hearts.

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