Vascular Endothelial Growth Factor Prevents Apoptosis and Preserves Contractile Function in Hypertrophied Infant Heart | Zendy

Ingeborg Friehs | Zendy; Rodrigo Barillas | Zendy; Nikolay V. Vasilyev | Zendy; Nathalie Roy | Zendy; Francis X. McGowan | Zendy; Pedro J. del Nido | Zendy

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Vascular Endothelial Growth Factor Prevents Apoptosis and Preserves Contractile Function in Hypertrophied Infant Heart

Author(s) -

Ingeborg Friehs,

Rodrigo Barillas,

Nikolay V. Vasilyev,

Nathalie Roy,

Francis X. McGowan,

Pedro J. del Nido

Publication year - 2006

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.105.001289

Subject(s) - medicine , apoptosis , cardiology , vascular endothelial growth factor , function (biology) , growth factor , microbiology and biotechnology , vegf receptors , receptor , biology , biochemistry , chemistry

Cardiac hypertrophy is an adaptive response to increased workload that, if unrelieved, leads to heart failure. It has been reported that cardiomyocyte apoptosis contributes to failure, and that vascular endothelial growth factor (VEGF) treatment of hypertrophied myocardium increases capillary density and improves myocardial perfusion. In this study we hypothesized that VEGF treatment reduces cardiomyocyte apoptosis and thereby preserves myocardial contractile function.

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