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Clinical Application of Tissue Engineered Human Heart Valves Using Autologous Progenitor Cells
Author(s) -
Serghei Cebotari,
Artur Lichtenberg,
I. Tudorache,
Andres Hilfiker,
Heike Mertsching,
Rainer Leyh,
Thomas Breymann,
Klaus Kallenbach,
Maniuc Liviu,
A Batrinac,
Repin Oleg,
Malîga Oxana,
Anatol Ciubotaru,
Axel Haverich
Publication year - 2006
Publication title -
circulation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.795
H-Index - 607
eISSN - 1524-4539
pISSN - 0009-7322
DOI - 10.1161/circulationaha.105.001065
Subject(s) - medicine , heart valve , cd31 , progenitor cell , decellularization , cardiology , heart failure , pulmonary valve , trypsinization , tissue engineering , stem cell , angiogenesis , biomedical engineering , trypsin , microbiology and biotechnology , biochemistry , chemistry , biology , enzyme
Tissue engineering (TE) of heart valves reseeded with autologous cells has been successfully performed in vitro. Here, we report our first clinical implantation of pulmonary heart valves (PV) engineered with autologous endothelial progenitor cells (EPCs) and the results of 3.5 years of follow-up.

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