Inflammatory Gene Polymorphisms and Risk of Postoperative Myocardial Infarction After Cardiac Surgery | Zendy

Mihai V. Podgoreanu | Zendy; WD White | Zendy; Richard Morris | Zendy; Joseph P. Mathew | Zendy; Mark StaffordSmith | Zendy; Ian J. Welsby | Zendy; Hilary P. Grocott | Zendy; Carmelo A. Milano | Zendy; Mark F. Newman | Zendy; Debra A. Schwinn | Zendy

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Inflammatory Gene Polymorphisms and Risk of Postoperative Myocardial Infarction After Cardiac Surgery

Author(s) -

Mihai V. Podgoreanu,

WD White,

Richard Morris,

Joseph P. Mathew,

Mark StaffordSmith,

Ian J. Welsby,

Hilary P. Grocott,

Carmelo A. Milano,

Mark F. Newman,

Debra A. Schwinn

Publication year - 2006

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.105.001032

Subject(s) - medicine , myocardial infarction , odds ratio , prospective cohort study , cardiac surgery , proinflammatory cytokine , bonferroni correction , cardiopulmonary bypass , cardiology , bioinformatics , inflammation , statistics , mathematics , biology

The inflammatory response triggered by cardiac surgery with cardiopulmonary bypass (CPB) is a primary mechanism in the pathogenesis of postoperative myocardial infarction (PMI), a multifactorial disorder with significant inter-patient variability poorly predicted by clinical and procedural factors. We tested the hypothesis that candidate gene polymorphisms in inflammatory pathways contribute to risk of PMI after cardiac surgery.

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