Expression of Matrix Metalloproteinases and Endogenous Inhibitors Within Ascending Aortic Aneurysms of Patients With Marfan Syndrome | Zendy

John S. Ikonomidis | Zendy; Jeffrey A. Jones | Zendy; John R. Barbour | Zendy; Robert E. Stroud | Zendy; Leslie L. Clark | Zendy; Brooke S. Kaplan | Zendy; Ahmed Zeeshan | Zendy; Joseph E. Bavaria | Zendy; Joseph H. Gorman | Zendy; Francis G. Spinale | Zendy; Robert C. Gorman | Zendy

Open Access

Expression of Matrix Metalloproteinases and Endogenous Inhibitors Within Ascending Aortic Aneurysms of Patients With Marfan Syndrome

Author(s) -

John S. Ikonomidis,

Jeffrey A. Jones,

John R. Barbour,

Robert E. Stroud,

Leslie L. Clark,

Brooke S. Kaplan,

Ahmed Zeeshan,

Joseph E. Bavaria,

Joseph H. Gorman,

Francis G. Spinale,

Robert C. Gorman

Publication year - 2006

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.105.000810

Subject(s) - medicine , marfan syndrome , matrix metalloproteinase , aortic aneurysm , cardiology , endogeny , aorta

Marfan syndrome (MFS) is known to cause ascending thoracic aortic aneurysms (ATAAs). Transforming growth factor beta (TGF-beta) has recently been implicated in this process. Imbalances between the matrix metalloproteinases (MMPs) and their endogenous inhibitors (TIMPs) have also been shown to contribute to aneurysm formation. Whether and to what degree MMP, TIMP, and TGF-beta signaling profiles are altered in ATAAs in MFS compared with non-MFS patients remains unknown.

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