Simultaneous Autologous Transplantation of Cocultured Mesenchymal Stem Cells and Skeletal Myoblasts Improves Ventricular Function in a Murine Model of Chagas Disease | Zendy

Luiz César Guarita-Souza | Zendy; Katherine Athayde Teixeira de Carvalho | Zendy; Vinícius Woitowicz | Zendy; CLK Rebelatto | Zendy; Alexandra Cristina Senegaglia | Zendy; Paula Hansen Suss | Zendy; Nelson Itiro Miyague | Zendy; Júlio César Francisco | Zendy; Márcia Olandoski | Zendy; José Rocha FariaNeto | Zendy; Paulo Brofman | Zendy

Open Access

Simultaneous Autologous Transplantation of Cocultured Mesenchymal Stem Cells and Skeletal Myoblasts Improves Ventricular Function in a Murine Model of Chagas Disease

Author(s) -

Luiz César Guarita-Souza,

Katherine Athayde Teixeira de Carvalho,

Vinícius Woitowicz,

CLK Rebelatto,

Alexandra Cristina Senegaglia,

Paula Hansen Suss,

Nelson Itiro Miyague,

Júlio César Francisco,

Márcia Olandoski,

José Rocha FariaNeto,

Paulo Brofman

Publication year - 2006

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.105.000646

Subject(s) - medicine , transplantation , ejection fraction , ventricle , mesenchymal stem cell , myocyte , stem cell , cardiomyopathy , cardiology , skeletal muscle , heart failure , pathology , biology , microbiology and biotechnology

Cellular transplantation is emerging as a promising strategy for the treatment of postinfarction ventricular dysfunction. Whether its beneficial effects can be extended to other cardiomyopathies remains an unexplored question. We evaluated the histological and functional effects of simultaneous autologous transplantation of co-cultured stem cells and skeletal myoblasts in an experimental model of dilated cardiomyopathy caused by Chagas disease, characterized by diffuse fibrosis and impairment of microcirculation.

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