Myocardial Expression of the Arginine:Glycine Amidinotransferase Gene Is Elevated in Heart Failure and Normalized After Recovery | Zendy

Martin E. Cullen | Zendy; Ada H. Y. Yuen | Zendy; Leanne E. Felkin | Zendy; Ryszard T. Smoleński | Zendy; Jennifer L. Hall | Zendy; Suzanne Grindle | Zendy; Leslie W. Miller | Zendy; Emma J. Birks | Zendy; Magdi H. Yacoub | Zendy; Paul J.R. Barton | Zendy

Open Access

Myocardial Expression of the Arginine:Glycine Amidinotransferase Gene Is Elevated in Heart Failure and Normalized After Recovery

Author(s) -

Martin E. Cullen,

Ada H. Y. Yuen,

Leanne E. Felkin,

Ryszard T. Smoleński,

Jennifer L. Hall,

Suzanne Grindle,

Leslie W. Miller,

Emma J. Birks,

Magdi H. Yacoub,

Paul J.R. Barton

Publication year - 2006

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.105.000448

Subject(s) - heart failure , medicine , heart transplantation , ventricular assist device , cardiology , gene expression , transplantation , gene , biochemistry , chemistry

Combination therapy consisting of mechanical unloading using a left ventricular assist device (LVAD) and pharmacological intervention can promote recovery from end-stage heart failure, but the mechanism is unknown. Preliminary microarray analysis revealed a significant and unexpected decrease in myocardial arginine:glycine amidinotransferase (AGAT) gene expression during recovery in these patients. The aim of this study was to evaluate the expression and role of AGAT expression in heart failure and recovery.

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