Myocardial Ischemia Induces Interleukin-6 and Tissue Factor Production in Patients With Coronary Artery Disease | Zendy

Ignatios Ikonomidis | Zendy; George Athanassopoulos | Zendy; John Lekakis | Zendy; Kyriaki Venetsanou | Zendy; Margarita Marinou | Zendy; Κimon Stamatelopoulos | Zendy; Dennis V. Cokkinos | Zendy; Petros Nihoyannopoulos | Zendy

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Myocardial Ischemia Induces Interleukin-6 and Tissue Factor Production in Patients With Coronary Artery Disease

Author(s) -

Ignatios Ikonomidis,

George Athanassopoulos,

John Lekakis,

Kyriaki Venetsanou,

Margarita Marinou,

Κimon Stamatelopoulos,

Dennis V. Cokkinos,

Petros Nihoyannopoulos

Publication year - 2005

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.104.532259

Subject(s) - medicine , dobutamine , coronary artery disease , ischemia , cardiology , cytokine , interleukin 6 , inotrope , macrophage colony stimulating factor , macrophage , hemodynamics , biochemistry , chemistry , in vitro

Interleukin-6 (IL-6) and macrophage colony stimulating factor plasma levels are elevated in acute coronary syndromes. IL-6 has an inherent negative inotropic action and, with tissue factor (TF), mediates the ischemia-reperfusion myocardial injury. We hypothesized that inducible ischemia leads to cytokine production, TF expression, and consequently persistent left ventricular dysfunction after dobutamine stress echocardiography (DSE) in coronary artery disease patients.

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