Degradation of Myosin Light Chain in Isolated Rat Hearts Subjected to Ischemia-Reperfusion Injury | Zendy

Grzegorz Sawicki | Zendy; Hernando León | Zendy; Jolanta Sawicka | Zendy; Meltem Sarıahmetoğlu | Zendy; Costas Schulze | Zendy; Paul G. Scott | Zendy; Danuta SzczesnaCordary | Zendy; Richard Schulz | Zendy

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Degradation of Myosin Light Chain in Isolated Rat Hearts Subjected to Ischemia-Reperfusion Injury

Author(s) -

Grzegorz Sawicki,

Hernando León,

Jolanta Sawicka,

Meltem Sarıahmetoğlu,

Costas Schulze,

Paul G. Scott,

Danuta SzczesnaCordary,

Richard Schulz

Publication year - 2005

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.104.531616

Subject(s) - myosin light chain kinase , ischemia , matrix metalloproteinase , medicine , myosin , zymography , biochemistry , reperfusion injury , microbiology and biotechnology , biology

Matrix metalloproteinase-2 (MMP-2) contributes to cardiac dysfunction resulting from ischemia-reperfusion (I/R) injury. MMP-2 not only remodels the extracellular matrix but also acts intracellularly in I/R by degrading troponin I. Whether other intracellular targets exist for MMP-2 during I/R is unknown.

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