Open AccessCerebral Vascular Dysfunction in Methionine Synthase–Deficient Mice
Author(s) -
Sanjana Dayal,
Angela M. Devlin,
Ryan B. McCaw,
MeiLan Liu,
Erland Arning,
Teodoro Bottiglieri,
Barry Shane,
Frank M. Faraci,
Steven R. Lentz
Publication year - 2005
Publication title -
circulation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.795
H-Index - 607
eISSN - 1524-4539
pISSN - 0009-7322
DOI - 10.1161/circulationaha.104.529248
Subject(s) - endocrinology , medicine , homocysteine , methionine , dilator , oxidative stress , cystathionine beta synthase , acetylcholine , biology , biochemistry , amino acid
Methionine synthase (MS) catalyzes the folate-dependent remethylation of homocysteine to methionine. We tested the hypothesis that deficiency of MS impairs endothelial function in mice heterozygous for disruption of the Mtr gene, which encodes MS.
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