Angiotensin-Converting Enzyme Inhibitors | Zendy

Hongmei Peng | Zendy; Oscar A. Carretero | Zendy; Nikola Vuljaj | Zendy; Tang-Dong Liao | Zendy; Apurva Motivala | Zendy; Edward L. Peterson | Zendy; Nour-Eddine Rhaleb | Zendy

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Angiotensin-Converting Enzyme Inhibitors

Author(s) -

Hongmei Peng,

Oscar A. Carretero,

Nikola Vuljaj,

Tang-Dong Liao,

Apurva Motivala,

Edward L. Peterson,

Nour-Eddine Rhaleb

Publication year - 2005

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.104.528695

Subject(s) - medicine , angiotensin converting enzyme , enzyme , pharmacology , biochemistry , blood pressure , chemistry

Angiotensin-converting enzyme (ACE) inhibitors are valuable agents for the treatment of hypertension, heart failure, and other cardiovascular and renal diseases. The cardioprotective effects of ACE inhibitors are mediated by blockade of both conversion of angiotensin (Ang) I to Ang II and kinin hydrolysis. Here, we report a novel mechanism that may explain the cardiac antifibrotic effect of ACE inhibition, involving blockade of the hydrolysis of N-acetyl-seryl-aspartyl-lysyl-proline (Ac-SDKP).

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