In Vivo Quantitative Measurement of Intact Fibrous Cap and Lipid-Rich Necrotic Core Size in Atherosclerotic Carotid Plaque | Zendy

Jianming Cai | Zendy; Thomas S. Hatsukami | Zendy; Marina S. Ferguson | Zendy; William Kerwin | Zendy; Tobias Saam | Zendy; Baocheng Chu | Zendy; Norihide Takaya | Zendy; Nayak L. Polissar | Zendy; Chun Yuan | Zendy

Open Access

In Vivo Quantitative Measurement of Intact Fibrous Cap and Lipid-Rich Necrotic Core Size in Atherosclerotic Carotid Plaque

Author(s) -

Jianming Cai,

Thomas S. Hatsukami,

Marina S. Ferguson,

William Kerwin,

Tobias Saam,

Baocheng Chu,

Norihide Takaya,

Nayak L. Polissar,

Chun Yuan

Publication year - 2005

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.104.528174

Subject(s) - fibrous cap , medicine , in vivo , core (optical fiber) , pathology , cardiology , biology , materials science , microbiology and biotechnology , composite material

Previous studies with contrast-enhanced magnetic resonance imaging (CEMRI) have shown that the fibrous cap (FC) in atherosclerotic carotid plaques enhances with gadolinium-based contrast agents. Conversely, the lipid-rich necrotic core (LR-NC), lacking both vasculature and matrix, shows no or only slight enhancement. The goal of this study was to assess whether CEMRI can be used to accurately measure the dimensions of the intact FC and LR-NC.

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