Oxidative Stress by Monoamine Oxidase Mediates Receptor-Independent Cardiomyocyte Apoptosis by Serotonin and Postischemic Myocardial Injury | Zendy

Pascale Bianchi | Zendy; Oksana Kunduzova | Zendy; Emanuela Masini | Zendy; Claudie Cambon | Zendy; Danièle Bani | Zendy; Laura Raimondi | Zendy; MarieHélène Séguélas | Zendy; Silvia Nistri | Zendy; Wilson S. Colucci | Zendy; Nathalie Leducq | Zendy; Angelo Parini | Zendy

Open Access

Oxidative Stress by Monoamine Oxidase Mediates Receptor-Independent Cardiomyocyte Apoptosis by Serotonin and Postischemic Myocardial Injury

Author(s) -

Pascale Bianchi,

Oksana Kunduzova,

Emanuela Masini,

Claudie Cambon,

Danièle Bani,

Laura Raimondi,

MarieHélène Séguélas,

Silvia Nistri,

Wilson S. Colucci,

Nathalie Leducq,

Angelo Parini

Publication year - 2005

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.104.528133

Subject(s) - oxidative stress , monoamine oxidase , pharmacology , medicine , apoptosis , monoamine oxidase a , downregulation and upregulation , serotonin , reactive oxygen species , ischemia , mitochondrion , receptor , endocrinology , microbiology and biotechnology , chemistry , biochemistry , biology , enzyme , gene

Serotonin (5-hydroxytryptamine [5-HT]), released by activated platelets during cardiac ischemia, is metabolized by the mitochondrial enzyme monoamine oxidase A (MAO-A). Because hydrogen peroxide is one of the byproducts of 5-HT degradation by MAO-A, we investigated the potential role of reactive oxygen species generated by MAOs in 5-HT-dependent cardiomyocyte death and post-ischemia-reperfusion cardiac damage.

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