Effects of l -Arginine on Fibroblast Growth Factor 2–Induced Angiogenesis in a Model of Endothelial Dysfunction | Zendy

Pierre Voisine | Zendy; Jian Li | Zendy; Cesario Bianchi | Zendy; Tanveer Ahmed Khan | Zendy; Marc Ruel | Zendy; Shuhua Xu | Zendy; Jun Feng | Zendy; Audrey Rosinberg | Zendy; Tamer Malik | Zendy; Yasunari Nakai | Zendy; Frank W. Sellke | Zendy

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Effects of l -Arginine on Fibroblast Growth Factor 2–Induced Angiogenesis in a Model of Endothelial Dysfunction

Author(s) -

Pierre Voisine,

Jian Li,

Cesario Bianchi,

Tanveer Ahmed Khan,

Marc Ruel,

Shuhua Xu,

Jun Feng,

Audrey Rosinberg,

Tamer Malik,

Yasunari Nakai,

Frank W. Sellke

Publication year - 2005

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.104.526350

Subject(s) - medicine , enos , fibroblast growth factor , endothelial dysfunction , angiogenesis , nitric oxide , endocrinology , endothelium , arginine , vascular endothelial growth factor , nitric oxide synthase , coronary artery disease , perfusion , endothelial stem cell , receptor , biochemistry , biology , in vitro , amino acid , vegf receptors

Nitric oxide availability, which is decreased in advanced coronary artery disease associated with endothelial dysfunction, is an important mediator of fibroblast growth factor-2 (FGF-2)-induced angiogenesis. This could explain the disappointing results of FGF-2 therapy in clinical trials despite promising preclinical studies. We examined the influence of L-arginine supplementation to FGF-2 therapy on myocardial microvascular reactivity and perfusion in a porcine model of endothelial dysfunction.

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