Novel Injectable Bioartificial Tissue Facilitates Targeted, Less Invasive, Large-Scale Tissue Restoration on the Beating Heart After Myocardial Injury | Zendy

Theo Kofidis | Zendy; Darren R. Lebl | Zendy; Eliana C. Martinez | Zendy; Grant Hoyt | Zendy; Masashi Tanaka | Zendy; Robert C. Robbins | Zendy

Open Access

Novel Injectable Bioartificial Tissue Facilitates Targeted, Less Invasive, Large-Scale Tissue Restoration on the Beating Heart After Myocardial Injury

Author(s) -

Theo Kofidis,

Darren R. Lebl,

Eliana C. Martinez,

Grant Hoyt,

Masashi Tanaka,

Robert C. Robbins

Publication year - 2005

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.104.526178

Subject(s) - medicine , matrigel , connexin , troponin i , cardiac function curve , angiogenesis , tissue engineering , artery , ischemia , myocardial infarction , cardiology , pathology , biomedical engineering , gap junction , heart failure , intracellular , chemistry , biochemistry

Implantation of bioartificial patches distorts myocardial geometry, and functional improvement of the recipient heart is usually attributed to reactive angiogenesis around the graft. With the liquid bioartificial tissue compound used in this study, we achieved targeted large-scale support of the infarcted left ventricular wall and improvement of heart function.

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