Effects of Deletion of theMatrix Metalloproteinase 9Gene on Development of Murine Thoracic Aortic Aneurysms | Zendy

John S. Ikonomidis | Zendy; John R. Barbour | Zendy; Zainab Amani | Zendy; Robert E. Stroud | Zendy; Amanda R. Herron | Zendy; David M. McClister | Zendy; Sarah E. Camens | Zendy; Merry L. Lindsey | Zendy; Rupak Mukherjee | Zendy; Francis G. Spinale | Zendy

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Effects of Deletion of theMatrix Metalloproteinase 9Gene on Development of Murine Thoracic Aortic Aneurysms

Author(s) -

John S. Ikonomidis,

John R. Barbour,

Zainab Amani,

Robert E. Stroud,

Amanda R. Herron,

David M. McClister,

Sarah E. Camens,

Merry L. Lindsey,

Rupak Mukherjee,

Francis G. Spinale

Publication year - 2005

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.104.526152

Subject(s) - matrix metalloproteinase , medicine , zymography , pathology , thoracic aorta , gelatinase a , knockout mouse , aortic aneurysm , thoracic aortic aneurysm , aorta , receptor

The matrix metalloproteinases (MMPs) contribute to cardiovascular remodeling, and MMPs, such as the gelatinases (MMP-9 and MMP-2), have been identified in thoracic aortic aneurysmal (TAA) tissue, but a cause-effect relationship has not been clearly established. Accordingly, this study examined TAA progression in mice devoid of the MMP-9 gene.

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