Aprotinin Preserves Cellular Junctions and Reduces Myocardial Edema After Regional Ischemia and Cardioplegic Arrest | Zendy

Tanveer Khan | Zendy; Cesario Bianchi | Zendy; Eugênio Gonçalves de Araújo | Zendy; Pierre Voisine | Zendy; Shuhua Xu | Zendy; Jun Feng | Zendy; Jian Li | Zendy; Frank W. Sellke | Zendy

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Aprotinin Preserves Cellular Junctions and Reduces Myocardial Edema After Regional Ischemia and Cardioplegic Arrest

Author(s) -

Tanveer Khan,

Cesario Bianchi,

Eugênio Gonçalves de Araújo,

Pierre Voisine,

Shuhua Xu,

Jun Feng,

Jian Li,

Frank W. Sellke

Publication year - 2005

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.104.526053

Subject(s) - aprotinin , medicine , anesthesia , ischemia , cardiopulmonary bypass , thrombin , edema , pharmacology , cardiology , platelet

Cardiac surgery with cardiopulmonary bypass (CPB) and cardioplegic arrest has been associated with myocardial edema attributable to vascular permeability, which is regulated in part by thrombin-induced alterations in cellular junctions. Aprotinin has been demonstrated to prevent activation of the thrombin protease-activated receptor, and we hypothesized that aprotinin preserves myocardial cellular junctions and prevents myocardial edema in a porcine model of regional ischemia and cardioplegic arrest.

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