Kruppel-Like Factor 2 as a Novel Mediator of Statin Effects in Endothelial Cells | Zendy

Sucharita SenBanerjee | Zendy; Samy S. Mir | Zendy; Zhiyong Lin | Zendy; Anne Hamik | Zendy; G. Brandon Atkins | Zendy; Hiranmoy Das | Zendy; Pallab Banerjee | Zendy; Ajay Kumar | Zendy; Mukesh K. Jain | Zendy

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Kruppel-Like Factor 2 as a Novel Mediator of Statin Effects in Endothelial Cells

Author(s) -

Sucharita SenBanerjee,

Samy S. Mir,

Zhiyong Lin,

Anne Hamik,

G. Brandon Atkins,

Hiranmoy Das,

Pallab Banerjee,

Ajay Kumar,

Mukesh K. Jain

Publication year - 2005

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.104.525774

Subject(s) - klf2 , enos , gene knockdown , thrombomodulin , statin , small interfering rna , transcription factor , enhancer , microbiology and biotechnology , endothelium , mediator , medicine , vascular endothelial growth factor b , biology , cancer research , nitric oxide , nitric oxide synthase , biochemistry , vascular endothelial growth factor , vascular endothelial growth factor a , rna , gene , platelet , thrombin , vegf receptors

Although 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors (statins) are known to modulate endothelial function, the transcriptional mechanisms underlying these effects are incompletely understood. We hypothesized that Lung-Kruppel-like factor (LKLF/KLF2), a novel and potent regulator of endothelial gene expression, may mediate the downstream effects of statins. Here we report that statin-induced expression of endothelial NO synthase (eNOS) and thrombomodulin is KLF2 dependent.

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