Maximizing Ventricular Function With Multimodal Cell-Based Gene Therapy | Zendy

Terrence M. Yau | Zendy; Christopher Kim | Zendy; Guangming Li | Zendy; Yaoguang Zhang | Zendy; Richard D. Weisel | Zendy; RenKe Li | Zendy

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Maximizing Ventricular Function With Multimodal Cell-Based Gene Therapy

Author(s) -

Terrence M. Yau,

Christopher Kim,

Guangming Li,

Yaoguang Zhang,

Richard D. Weisel,

RenKe Li

Publication year - 2005

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.104.525147

Subject(s) - medicine , vascular endothelial growth factor , transplantation , angiogenesis , apoptosis , tunel assay , insulin like growth factor , growth factor , andrology , endocrinology , immunohistochemistry , biology , vegf receptors , receptor , biochemistry

Angiogenesis is enhanced after transplantation of vascular endothelial growth factor (VEGF)-expressing cells into a myocardial scar. Insulin-like growth factor I (IGF-I) may induce hypertrophy and inhibit apoptosis. We evaluated the effect of cell-based IGF-I and VEGF multigene therapy on left ventricular (LV) function, cell survival, and apoptosis after bone marrow cell (BMC) transplantation.

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