Myocyte Volume and Function in Response to Osmotic Stress | Zendy

S. Mizutani | Zendy; Sandip M. Prasad | Zendy; Angela D. Sellitto | Zendy; Richard B. Schuessler | Zendy; Ralph J. Damiano | Zendy; Jennifer S. Lawton | Zendy

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Myocyte Volume and Function in Response to Osmotic Stress

Author(s) -

S. Mizutani,

Sandip M. Prasad,

Angela D. Sellitto,

Richard B. Schuessler,

Ralph J. Damiano,

Jennifer S. Lawton

Publication year - 2005

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.104.523746

Subject(s) - diazoxide , contractility , medicine , osmotic shock , myocyte , endocrinology , anesthesia , chemistry , biochemistry , insulin , gene

Hypothermic hyperkalemic cardioplegia results in significant myocyte swelling and impaired contractility. These detrimental effects may be eliminated by the addition of an adenosine triphosphate-sensitive potassium (KATP) channel opener. This study evaluated the hypothesis that a KATP channel opener (diazoxide) would benefit volume homeostasis by limiting volume and subsequent contractility changes during osmotic stress.

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