Diet-Induced Occlusive Coronary Atherosclerosis, Myocardial Infarction, Cardiac Dysfunction, and Premature Death in Scavenger Receptor Class B Type I-Deficient, Hypomorphic Apolipoprotein ER61 Mice | Zendy

Songwen Zhang | Zendy; Michael H. Picard | Zendy; Eliza Vasile | Zendy; Yu Zhu | Zendy; Robert L. Raffaı̈ | Zendy; Karl H. Weisgraber | Zendy; Monty Krieger | Zendy

Open Access

Diet-Induced Occlusive Coronary Atherosclerosis, Myocardial Infarction, Cardiac Dysfunction, and Premature Death in Scavenger Receptor Class B Type I-Deficient, Hypomorphic Apolipoprotein ER61 Mice

Author(s) -

Songwen Zhang,

Michael H. Picard,

Eliza Vasile,

Yu Zhu,

Robert L. Raffaı̈,

Karl H. Weisgraber,

Monty Krieger

Publication year - 2005

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.104.523563

Subject(s) - medicine , myocardial infarction , cardiology , scavenger receptor , coronary atherosclerosis , apolipoprotein b , cardiac dysfunction , endocrinology , coronary heart disease , cholesterol , lipoprotein , heart failure

Normal chow (low fat)-fed mice deficient in both the HDL receptor SR-BI and apolipoprotein E (SR-BI/apoE dKO) provide a distinctive model of coronary heart disease (CHD). They exhibit early-onset hypercholesterolemia characterized by unesterified cholesterol-rich abnormal lipoproteins (lamellar/vesicular and stacked discoidal particles), occlusive coronary atherosclerosis, spontaneous myocardial infarction, cardiac dysfunction, and premature death ( approximately 6 weeks of age). Mice in which similar features of CHD could be induced with a lipid-rich diet would represent a powerful tool to study CHD.

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