Metalloproteinase-2 and -9 in Giant Cell Arteritis | Zendy

Alicia Rodríguez-Pla | Zendy; Josep Angel Bosch-Gil | Zendy; José Rosselló-Urgell | Zendy; Pere Huguet-Redecilla | Zendy; John H. Stone | Zendy; Miquel VilardellTarrés | Zendy

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Metalloproteinase-2 and -9 in Giant Cell Arteritis

Author(s) -

Alicia Rodríguez-Pla,

Josep Angel Bosch-Gil,

José Rosselló-Urgell,

Pere Huguet-Redecilla,

John H. Stone,

Miquel VilardellTarrés

Publication year - 2005

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.104.520114

Subject(s) - vasa vasorum , internal elastic lamina , giant cell arteritis , medicine , pathology , elastin , pathophysiology , matrix metalloproteinase , immunohistochemistry , myofibroblast , hyperplasia , arteritis , biopsy , vasculitis , artery , disease , fibrosis

Both matrix metalloproteinase-2 (MMP-2) and -9 (MMP-9) have been postulated to play roles in the pathophysiology of giant cell arteritis (GCA) because of their ability to degrade elastin. Understanding the specific mediators of arterial damage in GCA could lead to new therapeutic targets in this disease.

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