Genetic Analysis of the Interleukin-18 System Highlights the Role of the Interleukin-18 Gene in Cardiovascular Disease | Zendy

Laurence Tiret | Zendy; Tiphaine Godefroy | Zendy; Edith Lubos | Zendy; Viviane Nicaud | Zendy; DavidAlexandre Trégouët | Zendy; Sandrine Barbaux | Zendy; Renate B. Schnabel | Zendy; Christoph Bickel | Zendy; Christine EspinolaKlein | Zendy; Odette Poirier | Zendy; Claire Perret | Zendy; Thomas Münzel | Zendy; H. J. Rupprecht | Zendy; Karl J. Lackner | Zendy; François Cambien | Zendy; Stefan Blankenberg | Zendy

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Genetic Analysis of the Interleukin-18 System Highlights the Role of the Interleukin-18 Gene in Cardiovascular Disease

Author(s) -

Laurence Tiret,

Tiphaine Godefroy,

Edith Lubos,

Viviane Nicaud,

DavidAlexandre Trégouët,

Sandrine Barbaux,

Renate B. Schnabel,

Christoph Bickel,

Christine EspinolaKlein,

Odette Poirier,

Claire Perret,

Thomas Münzel,

H. J. Rupprecht,

Karl J. Lackner,

François Cambien,

Stefan Blankenberg

Publication year - 2005

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.104.519702

Subject(s) - medicine , haplotype , interleukin 18 , quartile , disease , allele , genotype , interleukin , gene , genetics , cytokine , confidence interval , biology

Interleukin (IL)-18 plays a key role in atherosclerosis and its complications. The present study investigated the genetic variability of 4 genes of the IL-18 system-IL18, IL18R1, IL18RAP, and IL18BP-in relation to circulating IL-18 levels and cardiovascular mortality.

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