Increased Cardiac Expression of Tissue Inhibitor of Metalloproteinase-1 and Tissue Inhibitor of Metalloproteinase-2 Is Related to Cardiac Fibrosis and Dysfunction in the Chronic Pressure-Overloaded Human Heart | Zendy

Stéphane Heymans | Zendy; Blanche Schroen | Zendy; Pieter Vermeersch | Zendy; Hendrik Milting | Zendy; Fangye Gao | Zendy; Astrid Kassner | Zendy; Hilde Gillijns | Zendy; Paul Herijgers | Zendy; Willem Flameng | Zendy; Peter Carmeliet | Zendy; Frans Van de Werf | Zendy; Yigal M. Pinto | Zendy; Stefan Janssens | Zendy

Open Access

Increased Cardiac Expression of Tissue Inhibitor of Metalloproteinase-1 and Tissue Inhibitor of Metalloproteinase-2 Is Related to Cardiac Fibrosis and Dysfunction in the Chronic Pressure-Overloaded Human Heart

Author(s) -

Stéphane Heymans,

Blanche Schroen,

Pieter Vermeersch,

Hendrik Milting,

Fangye Gao,

Astrid Kassner,

Hilde Gillijns,

Paul Herijgers,

Willem Flameng,

Peter Carmeliet,

Frans Van de Werf,

Yigal M. Pinto,

Stefan Janssens

Publication year - 2005

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.104.516963

Subject(s) - medicine , tissue inhibitor of metalloproteinase , fibrosis , matrix metalloproteinase , metalloproteinase , myocardial fibrosis , cardiology , cardiac dysfunction , heart failure

Alterations in the balance of matrix metalloproteinases (MMPs) and their specific tissue inhibitors (TIMPs) are involved in left ventricular (LV) remodeling. Whether their expression is related to interstitial fibrosis or LV dysfunction in patients with chronic pressure overload-induced LV hypertrophy, however, is unknown.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research