Id1 Gene Transfer Confers Angiogenic Property on Fully Differentiated Endothelial Cells and Contributes to Therapeutic Angiogenesis | Zendy

Koichi Nishiyama | Zendy; Kentaro Takaji | Zendy; Keiichiro Kataoka | Zendy; Yukiko Kurihara | Zendy; Michihiro Yoshimura | Zendy; Atsushi Kato | Zendy; Hisao Ogawa | Zendy; Hiroki Kurihara | Zendy

Open Access

Id1 Gene Transfer Confers Angiogenic Property on Fully Differentiated Endothelial Cells and Contributes to Therapeutic Angiogenesis

Author(s) -

Koichi Nishiyama,

Kentaro Takaji,

Keiichiro Kataoka,

Yukiko Kurihara,

Michihiro Yoshimura,

Atsushi Kato,

Hisao Ogawa,

Hiroki Kurihara

Publication year - 2005

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.104.516898

Subject(s) - angiogenesis , transplantation , therapeutic angiogenesis , medicine , neovascularization , cancer research , matrigel , microbiology and biotechnology , immunology , pathology , biology

Transplantation of endothelial progenitor cells has been proposed as a potential strategy for therapeutic revascularization. However, the limited endogenous cell pool and the related technical difficulties constitute clinically important disadvantages to autologous transplantation. In this study we investigated whether fully differentiated endothelial cells (ECs) modified with gene transfer of Id1, a helix-loop-helix transcription factor involved in angiogenesis, have the potential to contribute to therapeutic angiogenesis.

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