Inhibition of Polymorphonuclear Leukocyte–Mediated Graft Damage Synergizes With Short-Term Costimulatory Blockade to Prevent Cardiac Allograft Rejection | Zendy

Tarek El-Sawy | Zendy; John A. Belperio | Zendy; Robert M. Strieter | Zendy; Daniel G. Remick | Zendy; Robert L. Fairchild | Zendy

Open Access

Inhibition of Polymorphonuclear Leukocyte–Mediated Graft Damage Synergizes With Short-Term Costimulatory Blockade to Prevent Cardiac Allograft Rejection

Author(s) -

Tarek El-Sawy,

John A. Belperio,

Robert M. Strieter,

Daniel G. Remick,

Robert L. Fairchild

Publication year - 2005

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.104.516708

Subject(s) - medicine , cxcl1 , cxcl2 , immunology , proinflammatory cytokine , blockade , inflammation , transplantation , infiltration (hvac) , chemokine , heart transplantation , receptor , chemokine receptor , physics , thermodynamics

The early inflammatory response during reperfusion of cardiac allografts is initiated by the infiltration of polymorphonuclear leukocytes (PMNs) into the graft. The impact of early PMN infiltration on allograft rejection compared with long-term graft survival remains poorly understood.

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