Expression of Human Myeloperoxidase by Macrophages Promotes Atherosclerosis in Mice | Zendy

Timothy S. McMillen | Zendy; Jay W. Heinecke | Zendy; Renee Leboeuf | Zendy

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Expression of Human Myeloperoxidase by Macrophages Promotes Atherosclerosis in Mice

Author(s) -

Timothy S. McMillen,

Jay W. Heinecke,

Renee Leboeuf

Publication year - 2005

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.104.516278

Subject(s) - medicine , myeloperoxidase , macrophage , inflammation , expression (computer science) , immunology , pathology , in vitro , biochemistry , biology , computer science , programming language

Myeloperoxidase (MPO) colocalizes with macrophages in the human artery wall, and its characteristic oxidation products have been detected in atherosclerotic lesions. Thus, oxidants produced by the enzyme might promote atherosclerosis. However, macrophages in mouse atherosclerotic tissue do not express MPO. Therefore, mice are an inappropriate model for testing the role of MPO in vascular disease. To overcome this problem, we generated and studied transgenic (Tg) mice that contained the human MPO gene.

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