Abdominal Aortic Aneurysm Is Associated With High Serum Levels of Tenascin-X and Decreased Aneurysmal Tissue Tenascin-X | Zendy

Ma C. Zweers | Zendy; A. C. T. M. Peeters | Zendy; Sietze J. Graafsma | Zendy; Steef Kranendonk | Zendy; J. Adam van der Vliet | Zendy; Martin den Heijer | Zendy; Joost Schalkwijk | Zendy

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Abdominal Aortic Aneurysm Is Associated With High Serum Levels of Tenascin-X and Decreased Aneurysmal Tissue Tenascin-X

Author(s) -

Ma C. Zweers,

A. C. T. M. Peeters,

Sietze J. Graafsma,

Steef Kranendonk,

J. Adam van der Vliet,

Martin den Heijer,

Joost Schalkwijk

Publication year - 2006

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.104.513820

Subject(s) - tenascin , tenascin c , elastin , medicine , aorta , connective tissue , extracellular matrix , abdominal aorta , abdominal aortic aneurysm , aortic aneurysm , adventitia , pathology , endocrinology , aneurysm , immunohistochemistry , biology , surgery , biochemistry , fibronectin

Tenascin-X is a large extracellular matrix protein that is abundantly expressed in several connective tissues. A 140-kDa C-terminal fragment of tenascin-X is present in human serum. Complete deficiency of tenascin-X is associated with Ehlers-Danlos syndrome, and these patients show major connective tissue alterations in their skin, as well as blood vessel fragility. In this study, we investigated whether tenascin-X is present in normal human aorta and abdominal aortic aneurysm (AAA) tissues and whether an association exists between serum tenascin-X levels and AAA.

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