Nuclear Magnetic Resonance Lipoprotein Abnormalities in Prediabetic Subjects in the Insulin Resistance Atherosclerosis Study | Zendy

Andreas Festa | Zendy; Ken Williams | Zendy; Anthony J. Hanley | Zendy; James D. Otvos | Zendy; David C. Goff | Zendy; Lynne E. Wagenknecht | Zendy; Steven M. Haffner | Zendy

Open Access

Nuclear Magnetic Resonance Lipoprotein Abnormalities in Prediabetic Subjects in the Insulin Resistance Atherosclerosis Study

Author(s) -

Andreas Festa,

Ken Williams,

Anthony J. Hanley,

James D. Otvos,

David C. Goff,

Lynne E. Wagenknecht,

Steven M. Haffner

Publication year - 2005

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.104.512079

Subject(s) - medicine , insulin resistance , endocrinology , very low density lipoprotein , diabetes mellitus , dyslipidemia , lipoprotein , cholesterol , odds ratio , insulin , type 2 diabetes

Subjects with type 2 diabetes have smaller LDL and HDL particles in addition to higher levels of triglycerides and lower HDL cholesterol. Elevated insulin resistance, blood pressure, and dyslipidemia (including small dense LDL) predicted incident diabetes. In the Insulin Resistance Atherosclerosis Study (IRAS) we studied nuclear magnetic resonance (NMR) lipoprotein particle measures in prediabetic individuals, considering potentially modifying covariates, including insulin resistance, as directly measured using a frequently sampled intravenous glucose tolerance test.

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