Cardiospecific Overexpression of the Prostaglandin EP 3 Receptor Attenuates Ischemia-Induced Myocardial Injury | Zendy

Melanie Martin | Zendy; Jutta Meyer-Kirchrath | Zendy; Gernot Kaber | Zendy; Christoph Jacoby | Zendy; Ulrich Flögel | Zendy; Jürgen Schrader | Zendy; Ulrich Rüther | Zendy; Karsten Schrör | Zendy; Thomas Hohlfeld | Zendy

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Cardiospecific Overexpression of the Prostaglandin EP ₃ Receptor Attenuates Ischemia-Induced Myocardial Injury

Author(s) -

Melanie Martin,

Jutta Meyer-Kirchrath,

Gernot Kaber,

Christoph Jacoby,

Ulrich Flögel,

Jürgen Schrader,

Ulrich Rüther,

Karsten Schrör,

Thomas Hohlfeld

Publication year - 2005

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.104.508333

Subject(s) - medicine , ischemia , myocardial ischemia , prostaglandin , cardiology , receptor , reperfusion injury

The generation of prostaglandin E2 (PGE2) is significantly increased in acute myocardial ischemia and reperfusion. PGE2, in addition to other prostaglandins, protects the reperfused ischemic myocardium. It has been hypothesized that this cardioprotection is mediated by E-type prostaglandin receptors of the Gi-coupled EP3 subtype.

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