α-Myosin Heavy Chain | Zendy

Elisa Carniel | Zendy; Matthew R.G. Taylor | Zendy; Gianfranco Sinagra | Zendy; Andrea Di Lenarda | Zendy; Lisa Ku | Zendy; Pamela R. Fain | Zendy; Mark M. Boucek | Zendy; Jean Cavanaugh | Zendy; Snježana Miočiċ | Zendy; Dobromir Slavov | Zendy; Sharon Graw | Zendy; Jennie Feiger | Zendy; Xiao Zhu | Zendy; Dmi Dao | Zendy; Debra A. Ferguson | Zendy; Michael R. Bristow | Zendy; Luisa Mestroni | Zendy

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α-Myosin Heavy Chain

Author(s) -

Elisa Carniel,

Matthew R.G. Taylor,

Gianfranco Sinagra,

Andrea Di Lenarda,

Lisa Ku,

Pamela R. Fain,

Mark M. Boucek,

Jean Cavanaugh,

Snježana Miočiċ,

Dobromir Slavov,

Sharon Graw,

Jennie Feiger,

Xiao Zhu,

Dmi Dao,

Debra A. Ferguson,

Michael R. Bristow,

Luisa Mestroni

Publication year - 2005

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.104.507699

Subject(s) - myh6 , medicine , missense mutation , hypertrophic cardiomyopathy , myh7 , proband , mutation , genetics , phenotype , cardiology , gene , biology , gene isoform

Mutations in the beta-myosin heavy-chain (betaMyHC) gene cause hypertrophic (HCM) and dilated (DCM) forms of cardiomyopathy. In failing human hearts, downregulation of alphaMyHC mRNA or protein has been correlated with systolic dysfunction. We hypothesized that mutations in alphaMyHC could also lead to pleiotropic cardiac phenotypes, including HCM and DCM.

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