C-Reactive Protein and Cerebral Small-Vessel Disease | Zendy

Ewoud J. van Dijk | Zendy; Niels D. Prins | Zendy; Sarah E. Vermeer | Zendy; Henri A. Vrooman | Zendy; Albert Hofman | Zendy; Peter J. Koudstaal | Zendy; Monique M.B. Breteler | Zendy

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C-Reactive Protein and Cerebral Small-Vessel Disease

Author(s) -

Ewoud J. van Dijk,

Niels D. Prins,

Sarah E. Vermeer,

Henri A. Vrooman,

Albert Hofman,

Peter J. Koudstaal,

Monique M.B. Breteler

Publication year - 2005

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.104.506337

Subject(s) - medicine , leukoaraiosis , hyperintensity , white matter , stroke (engine) , c reactive protein , lesion , dementia , population , lacunar stroke , pathology , cardiology , vascular disease , magnetic resonance imaging , disease , radiology , inflammation , ischemia , ischemic stroke , mechanical engineering , environmental health , engineering

Inflammatory processes are involved in the development and consequences of atherosclerosis. Whether these processes are also involved in cerebral small-vessel disease is unknown. Cerebral white matter lesions and lacunar brain infarcts are caused by small-vessel disease and are commonly observed on MRI scans in elderly people. These lesions are associated with an increased risk of stroke and dementia. We assessed whether higher C-reactive protein (CRP) levels were related to white matter lesion and lacunar infarcts.

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