Improved Myocardial β-Adrenergic Responsiveness and Signaling With Exercise Training in Hypertension | Zendy

Scott M. MacDonnell | Zendy; Hajime Kubo | Zendy; Deborah L. Crabbe | Zendy; Brian F. Renna | Zendy; Patricia O. Reger | Zendy; Jun Mohara | Zendy; L. Ashley Smithwick | Zendy; Walter J. Koch | Zendy; Steven R. Houser | Zendy; Joseph R. Libonati | Zendy

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Improved Myocardial β-Adrenergic Responsiveness and Signaling With Exercise Training in Hypertension

Author(s) -

Scott M. MacDonnell,

Hajime Kubo,

Deborah L. Crabbe,

Brian F. Renna,

Patricia O. Reger,

Jun Mohara,

L. Ashley Smithwick,

Walter J. Koch,

Steven R. Houser,

Joseph R. Libonati

Publication year - 2005

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.104.505784

Subject(s) - medicine , endocrinology , lusitropy , pressure overload , blood pressure , diastole , muscle hypertrophy , heart rate , adrenergic receptor , spontaneously hypertensive rat , receptor , cardiac hypertrophy

Cardiac responses to beta-adrenergic receptor stimulation are depressed with pressure overload-induced cardiac hypertrophy. We investigated whether exercise training could modify beta-adrenergic receptor responsiveness in a model of spontaneous hypertension by modifying the beta-adrenergic receptor desensitizing kinase GRK2 and the abundance and phosphorylation of some key Ca2+ cycling proteins.

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