In Vivo Cell Seeding With Anti-CD34 Antibodies Successfully Accelerates Endothelialization but Stimulates Intimal Hyperplasia in Porcine Arteriovenous Expanded Polytetrafluoroethylene Grafts | Zendy

Jan Rotmans | Zendy; Jan M.M. Heyligers | Zendy; Hence J.M. Verhagen | Zendy; Evelyn Velema | Zendy; Machiel M. Nagtegaal | Zendy; Dominique P.V. de Kleijn | Zendy; Flip G. de Groot | Zendy; Erik S.G. Stroes | Zendy; Gerard Pasterkamp | Zendy

Open Access

In Vivo Cell Seeding With Anti-CD34 Antibodies Successfully Accelerates Endothelialization but Stimulates Intimal Hyperplasia in Porcine Arteriovenous Expanded Polytetrafluoroethylene Grafts

Author(s) -

Jan Rotmans,

Jan M.M. Heyligers,

Hence J.M. Verhagen,

Evelyn Velema,

Machiel M. Nagtegaal,

Dominique P.V. de Kleijn,

Flip G. de Groot,

Erik S.G. Stroes,

Gerard Pasterkamp

Publication year - 2005

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.104.504407

Subject(s) - medicine , intimal hyperplasia , in vivo , polytetrafluoroethylene , seeding , cd34 , antibody , hyperplasia , pathology , smooth muscle , stem cell , microbiology and biotechnology , immunology , biology , materials science , engineering , metallurgy , aerospace engineering

The patency of AV expanded polytetrafluoroethylene (ePTFE) grafts for hemodialysis is impaired by intimal hyperplasia (IH) at the venous outflow tract. The absence of a functional endothelial monolayer on the prosthetic grafts is an important stimulus for IH. In the present study, we evaluated the feasibility of capturing endothelial progenitor cells in vivo using anti-CD34 antibodies on ePTFE grafts to inhibit IH in porcine AV ePTFE grafts.

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