Reduced Number of Circulating Endothelial Progenitor Cells Predicts Future Cardiovascular Events | Zendy

Caroline SchmidtLucke | Zendy; Lothar Rössig | Zendy; Stephan Fichtlscherer | Zendy; Mariuca Vasa | Zendy; Martina Britten | Zendy; Ulrike Kämper | Zendy; Stefanie Dimmeler | Zendy; Andreas M. Zeiher | Zendy

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Reduced Number of Circulating Endothelial Progenitor Cells Predicts Future Cardiovascular Events

Author(s) -

Caroline SchmidtLucke,

Lothar Rössig,

Stephan Fichtlscherer,

Mariuca Vasa,

Martina Britten,

Ulrike Kämper,

Stefanie Dimmeler,

Andreas M. Zeiher

Publication year - 2005

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.104.504340

Subject(s) - medicine , progenitor cell , endothelial progenitor cell , cardiology , endothelial stem cell , stem cell , microbiology and biotechnology , in vitro , biology , biochemistry , chemistry

The maintenance of endothelial integrity plays a critical role in preventing atherosclerotic disease progression. Endothelial progenitor cells (EPCs) were experimentally shown to incorporate into sites of neovascularization and home to sites of endothelial denudation. Circulating EPCs may thus provide an endogenous repair mechanism to counteract ongoing risk factor-induced endothelial injury and to replace dysfunctional endothelium.

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