Conditional Mineralocorticoid Receptor Expression in the Heart Leads to Life-Threatening Arrhythmias | Zendy

Antoine OuvrardPascaud | Zendy; Yannis Sainte–Marie | Zendy; JeanPierre Bénitah | Zendy; Romain Perrier | Zendy; Christelle Soukaseum | Zendy; Aurélie Nguyen Dinh Cat | Zendy; Anne Royer | Zendy; Khaï Le Quang | Zendy; Flavien Charpentier | Zendy; Sophie Demolombe | Zendy; Fatima MechtaGrigoriou | Zendy; Ahmed Beggah | Zendy; Pierre MaisonBlanche | Zendy; M. E. Oblin | Zendy; Claude Delcayre | Zendy; Glenn I. Fishman | Zendy; Nicolette Farman | Zendy; Brigitte Escoubet | Zendy; Frédéric Jaisser | Zendy

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Conditional Mineralocorticoid Receptor Expression in the Heart Leads to Life-Threatening Arrhythmias

Author(s) -

Antoine OuvrardPascaud,

Yannis Sainte–Marie,

JeanPierre Bénitah,

Romain Perrier,

Christelle Soukaseum,

Aurélie Nguyen Dinh Cat,

Anne Royer,

Khaï Le Quang,

Flavien Charpentier,

Sophie Demolombe,

Fatima MechtaGrigoriou,

Ahmed Beggah,

Pierre MaisonBlanche,

M. E. Oblin,

Claude Delcayre,

Glenn I. Fishman,

Nicolette Farman,

Brigitte Escoubet,

Frédéric Jaisser

Publication year - 2005

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.104.503706

Subject(s) - medicine , mineralocorticoid receptor , mineralocorticoid , endocrinology , receptor , cardiology

Life-threatening cardiac arrhythmia is a major source of mortality worldwide. Besides rare inherited monogenic diseases such as long-QT or Brugada syndromes, which reflect abnormalities in ion fluxes across cardiac ion channels as a final common pathway, arrhythmias are most frequently acquired and associated with heart disease. The mineralocorticoid hormone aldosterone is an important contributor to morbidity and mortality in heart failure, but its mechanisms of action are incompletely understood.

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