Statin Treatment After Onset of Sepsis in a Murine Model Improves Survival | Zendy

Marc W. Merx | Zendy; Elisa A. Liehn | Zendy; Jürgen Graf | Zendy; Annette van de Sandt | Zendy; Maren Schaltenbrand | Zendy; Jürgen Schrader | Zendy; Peter Hanrath | Zendy; Christian Weber | Zendy

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Statin Treatment After Onset of Sepsis in a Murine Model Improves Survival

Author(s) -

Marc W. Merx,

Elisa A. Liehn,

Jürgen Graf,

Annette van de Sandt,

Maren Schaltenbrand,

Jürgen Schrader,

Peter Hanrath,

Christian Weber

Publication year - 2005

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.104.502195

Subject(s) - medicine , sepsis , statin , hydroxymethylglutaryl coa reductase inhibitors , cardiology

HMG-CoA-reductase inhibitors have been shown to exhibit pronounced immunomodulatory effects independent of lipid lowering. We have recently demonstrated that pretreatment with simvastatin profoundly improves survival in a cecal ligation and perforation (CLP) model of sepsis. Here, we studied whether treatment with simvastatin after onset of sepsis-induced hemodynamic alterations is beneficial and whether prolonged survival can also be achieved with other statins.

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