From Stem Cells to Viable Autologous Semilunar Heart Valve | Zendy

Fraser Sutherland | Zendy; Tjörvi E. Perry | Zendy; Ying Yu | Zendy; Megan C. Sherwood | Zendy; Elena Rabkin | Zendy; Yutaka Masuda | Zendy; G. Alejandra Garcia | Zendy; Dawn L. McLellan | Zendy; George C. Engelmayr | Zendy; Michael S. Sacks | Zendy; Frederick J. Schoen | Zendy; John E. Mayer | Zendy

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From Stem Cells to Viable Autologous Semilunar Heart Valve

Author(s) -

Fraser Sutherland,

Tjörvi E. Perry,

Ying Yu,

Megan C. Sherwood,

Elena Rabkin,

Yutaka Masuda,

G. Alejandra Garcia,

Dawn L. McLellan,

George C. Engelmayr,

Michael S. Sacks,

Frederick J. Schoen,

John E. Mayer

Publication year - 2005

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.104.498378

Subject(s) - mesenchymal stem cell , stem cell , medicine , heart valve , progenitor cell , tissue engineering , pathology , biomedical engineering , cardiology , microbiology and biotechnology , biology

An estimated 275,000 patients undergo heart valve replacement each year. However, existing solutions for valve replacement are complicated by the morbidity associated with lifelong anticoagulation of mechanical valves and the limited durability of bioprostheses. Recent advances in tissue engineering and our understanding of stem cell biology may provide a lifelong solution to these problems.

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