Placental Growth Factor Promotes Atherosclerotic Intimal Thickening and Macrophage Accumulation | Zendy

Rohit Khurana | Zendy; Lieve Moons | Zendy; Shahida Shafi | Zendy; Aernout Luttun | Zendy; D Collen | Zendy; John F. Martin | Zendy; Peter Carmeliet | Zendy; Ian Zachary | Zendy

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Placental Growth Factor Promotes Atherosclerotic Intimal Thickening and Macrophage Accumulation

Author(s) -

Rohit Khurana,

Lieve Moons,

Shahida Shafi,

Aernout Luttun,

D Collen,

John F. Martin,

Peter Carmeliet,

Ian Zachary

Publication year - 2005

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.104.495887

Subject(s) - medicine , neointima , placental growth factor , macrophage , apolipoprotein e , angiogenesis , apolipoprotein b , pathogenesis , pathology , vascular disease , endocrinology , vascular endothelial growth factor , cholesterol , disease , in vitro , biology , restenosis , biochemistry , stent , vegf receptors

Placental growth factor (PlGF) has been implicated in the pathophysiological angiogenesis and monocyte recruitment that underlie chronic inflammatory disease, but its role in atherosclerosis has not been examined. We investigated the effects of exogenous PlGF, delivered by adenoviral gene transfer, on atherogenic intimal thickening and macrophage accumulation induced by collar placement around the rabbit carotid artery and examined the effects of PlGF deficiency on atherosclerosis in apolipoprotein E-deficient (apoE(-/-)) mice.

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