Immunoglobulin M-to-Immunoglobulin G Anti-Human Leukocyte Antigen Class II Antibody Switching in Cardiac Transplant Recipients Is Associated With an Increased Risk of Cellular Rejection and Coronary Artery Disease | Zendy

Katherine Lietz | Zendy; Ranjit John | Zendy; Elizabeth Burke | Zendy; Michael Schuster | Zendy; Tyson Rogers | Zendy; Nicole SuciuFoca | Zendy; Donna Mancini | Zendy; Silviu Itescu | Zendy

Open Access

Immunoglobulin M-to-Immunoglobulin G Anti-Human Leukocyte Antigen Class II Antibody Switching in Cardiac Transplant Recipients Is Associated With an Increased Risk of Cellular Rejection and Coronary Artery Disease

Author(s) -

Katherine Lietz,

Ranjit John,

Elizabeth Burke,

Michael Schuster,

Tyson Rogers,

Nicole SuciuFoca,

Donna Mancini,

Silviu Itescu

Publication year - 2005

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.104.485003

Subject(s) - isotype , immunoglobulin class switching , immunology , human leukocyte antigen , antibody , medicine , antigen , transplantation , immunoglobulin g , t cell , immune system , b cell , monoclonal antibody

Activation of T cells induces immunoglobulin (Ig)M-to-IgG B-cell isotype switching via costimulatory regulatory pathways. Because rejection of transplanted organs is preceded by alloantigen-dependent T-cell activation, we investigated whether B-cell isotype switching could predict acute cellular rejection and the subsequent development of transplantation-related coronary artery disease (TCAD) in cardiac transplant recipients.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research