Cellular Mechanisms Underlying the Development of Catecholaminergic Ventricular Tachycardia | Zendy

GiByoung Nam | Zendy; Alexander Burashnikov | Zendy; Charles Antzelevitch | Zendy

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Cellular Mechanisms Underlying the Development of Catecholaminergic Ventricular Tachycardia

Author(s) -

GiByoung Nam,

Alexander Burashnikov,

Charles Antzelevitch

Publication year - 2005

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.104.479295

Subject(s) - medicine , catecholaminergic polymorphic ventricular tachycardia , catecholaminergic , cardiology , ventricular tachycardia , neuroscience , dopamine , ryanodine receptor 2 , receptor , ryanodine receptor , biology

Mutations in the ryanodine 2 receptor (RyR2) gene have been identified in patients with catecholaminergic polymorphic ventricular tachycardia. We examined the cellular basis for the ECG features and arrhythmia mechanisms using low-dose caffeine to mimic the defective calcium homeostasis encountered under these conditions.

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