Calcified Rheumatic Valve Neoangiogenesis Is Associated With Vascular Endothelial Growth Factor Expression and Osteoblast-Like Bone Formation | Zendy

Nalini M. Rajamannan | Zendy; Thomas B. Nealis | Zendy; Malayannan Subramaniam | Zendy; S.U. Pandya | Zendy; Stuart R. Stock | Zendy; Constatine I. Ignatiev | Zendy; Thomas J. Sebo | Zendy; Todd K. Rosengart | Zendy; William D. Edwards | Zendy; Patrick M. McCarthy | Zendy; Robert O. Bonow | Zendy; Thomas C. Spelsberg | Zendy

Open Access

Calcified Rheumatic Valve Neoangiogenesis Is Associated With Vascular Endothelial Growth Factor Expression and Osteoblast-Like Bone Formation

Author(s) -

Nalini M. Rajamannan,

Thomas B. Nealis,

Malayannan Subramaniam,

S.U. Pandya,

Stuart R. Stock,

Constatine I. Ignatiev,

Thomas J. Sebo,

Todd K. Rosengart,

William D. Edwards,

Patrick M. McCarthy,

Robert O. Bonow,

Thomas C. Spelsberg

Publication year - 2005

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.104.473165

Subject(s) - medicine , osteoblast , vascular endothelial growth factor , growth factor , cardiology , vegf receptors , biochemistry , in vitro , chemistry , receptor

Rheumatic heart disease is the most common cause of valvular disease in developing countries. Despite the high prevalence of this disease, the cellular mechanisms are not well known. We hypothesized that rheumatic valve calcification is associated with an osteoblast bone formation and neoangiogenesis.

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