Prognostic Value of Plasma N-Terminal Pro-Brain Natriuretic Peptide in Patients With Severe Sepsis | Zendy

Martina Brueckmann | Zendy; G. Huhle | Zendy; Siegfried Lang | Zendy; Karl K. Haase | Zendy; Thomas Bertsch | Zendy; Christel Weiß | Zendy; Jens J. Kaden | Zendy; Christian Putensen | Zendy; Martin Borggrefe | Zendy; Ursula Hoffmann | Zendy

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Prognostic Value of Plasma N-Terminal Pro-Brain Natriuretic Peptide in Patients With Severe Sepsis

Author(s) -

Martina Brueckmann,

G. Huhle,

Siegfried Lang,

Karl K. Haase,

Thomas Bertsch,

Christel Weiß,

Jens J. Kaden,

Christian Putensen,

Martin Borggrefe,

Ursula Hoffmann

Publication year - 2005

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.104.472050

Subject(s) - medicine , natriuretic peptide , sepsis , heart failure , context (archaeology) , cardiology , brain natriuretic peptide , septic shock , prohormone , population , troponin , n terminal pro brain natriuretic peptide , troponin t , myocardial infarction , paleontology , environmental health , hormone , biology

Increased plasma levels of atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP) have been identified as predictors of cardiac dysfunction and prognosis in congestive heart failure and ischemic heart disease. In severe sepsis patients, however, no information is available yet about the prognostic value of natriuretic peptides. Therefore, the aim of the present study was to determine the role of the N-terminal prohormone forms of ANP (NT-proANP) and BNP (NT-proBNP) in the context of outcome of septic patients. Furthermore, the effect of treatment with recombinant human activated protein C [drotrecogin alfa (activated)] on plasma levels of natriuretic peptides in severe sepsis was evaluated.

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