Open AccessTargeted Ablation of Periostin-Expressing Activated Fibroblasts Prevents Adverse Cardiac Remodeling in Mice
Author(s) -
Harmandeep Kaur,
Mikito Takefuji,
CW Ngai,
Jorge Carvalho,
J. M. Bayer,
Astrid Wietelmann,
Ansgar Poetsch,
Soraya Hoelper,
Simon J. Conway,
Helge Möllmann,
Mario Looso,
Christian Troidl,
Stefan Offermanns,
Nina Wettschureck
Publication year - 2016
Publication title -
circulation research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.899
H-Index - 336
eISSN - 1524-4571
pISSN - 0009-7330
DOI - 10.1161/circresaha.116.308643
Subject(s) - periostin , ventricular remodeling , microbiology and biotechnology , medicine , cancer research , chemistry , cardiology , biology , heart failure , extracellular matrix
Activated cardiac fibroblasts (CF) are crucial players in the cardiac damage response; excess fibrosis, however, may result in myocardial stiffening and heart failure development. Inhibition of activated CF has been suggested as a therapeutic strategy in cardiac disease, but whether this truly improves cardiac function is unclear.
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