Open AccessProtective Roles of Endothelial AMP-Activated Protein Kinase Against Hypoxia-Induced Pulmonary Hypertension in Mice
Author(s) -
Junichi Omura,
Kimio Satoh,
Nobuhiro Kikuchi,
Taijyu Satoh,
Ryo Kurosawa,
Masamichi Nogi,
Tomohiro Otsuki,
Katsuya Kozu,
Kazuhiko Numano,
Kota Suzuki,
Shinichiro Sunamura,
Shunsuke Tatebe,
Tatsuo Aoki,
Koichiro Sugimura,
Satoshi Miyata,
Yasushi Hoshikawa,
Yoshinori Okada,
Hiroaki Shimokawa
Publication year - 2016
Publication title -
circulation research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.899
H-Index - 336
eISSN - 1524-4571
pISSN - 0009-7330
DOI - 10.1161/circresaha.115.308178
Subject(s) - ampk , hypoxia (environmental) , pulmonary hypertension , medicine , endocrinology , protein kinase a , amp activated protein kinase , endothelial stem cell , endothelium , biology , chemistry , kinase , microbiology and biotechnology , biochemistry , in vitro , oxygen , organic chemistry
Endothelial AMP-activated protein kinase (AMPK) plays an important role for vascular homeostasis, and its role is impaired by vascular inflammation. However, the role of endothelial AMPK in the pathogenesis of pulmonary arterial hypertension (PAH) remains to be elucidated.
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