Open AccessUnique Features of Cortical Bone Stem Cells Associated With Repair of the Injured Heart
Author(s) -
Sadia Mohsin,
Constantine D. Troupes,
Timothy Starosta,
Thomas E. Sharp,
Elorm J. Agra,
Shavonn Smith,
Jason M. Duran,
Neil Zalavadia,
Yan Zhou,
Hajime Kubo,
Remus M. Berretta,
Steven R. Houser
Publication year - 2015
Publication title -
circulation research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.899
H-Index - 336
eISSN - 1524-4571
pISSN - 0009-7330
DOI - 10.1161/circresaha.115.307362
Subject(s) - stem cell , mesenchymal stem cell , microbiology and biotechnology , population , biology , stem cell transplantation for articular cartilage repair , stem cell therapy , adult stem cell , immunology , cancer research , endothelial stem cell , medicine , in vitro , environmental health , biochemistry
Adoptive transfer of multiple stem cell types has only had modest effects on the structure and function of failing human hearts. Despite increasing the use of stem cell therapies, consensus on the optimal stem cell type is not adequately defined. The modest cardiac repair and functional improvement in patients with cardiac disease warrants identification of a novel stem cell population that possesses properties that induce a more substantial improvement in patients with heart failure.
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