Endothelial Actions of ANP Enhance Myocardial Inflammatory Infiltration in the Early Phase After Acute Infarction | Zendy

Wen Chen | Zendy; Annett Spitzl | Zendy; Denise Mathes | Zendy; Viacheslav O. Nikolaev | Zendy; Franziska Werner | Zendy; Johannes Weirather | Zendy; Katarina Špiranec | Zendy; Katharina Röck | Zendy; Jens W. Fischer | Zendy; Ulrike Kämmerer | Zendy; David Stegner | Zendy; Hideo A. Baba | Zendy; Ulrich Hofmann | Zendy; Stefan Frantz | Zendy; Michaela Kühn | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Endothelial Actions of ANP Enhance Myocardial Inflammatory Infiltration in the Early Phase After Acute Infarction

Author(s) -

Wen Chen,

Annett Spitzl,

Denise Mathes,

Viacheslav O. Nikolaev,

Franziska Werner,

Johannes Weirather,

Katarina Špiranec,

Katharina Röck,

Jens W. Fischer,

Ulrike Kämmerer,

David Stegner,

Hideo A. Baba,

Ulrich Hofmann,

Stefan Frantz,

Michaela Kühn

Publication year - 2016

Publication title -

circulation research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 4.899

H-Index - 336

eISSN - 1524-4571

pISSN - 0009-7330

DOI - 10.1161/circresaha.115.307196

Subject(s) - tumor necrosis factor alpha , inflammation , knockout mouse , endothelial dysfunction , phosphodiesterase , medicine , necrosis , endothelial activation , endocrinology , hypoxia (environmental) , microcirculation , cancer research , immunology , biology , receptor , chemistry , biochemistry , enzyme , organic chemistry , oxygen

In patients after acute myocardial infarction (AMI), the initial extent of necrosis and inflammation determine clinical outcome. One early event in AMI is the increased cardiac expression of atrial natriuretic peptide (NP) and B-type NP, with their plasma levels correlating with severity of ischemia. It was shown that NPs, via their cGMP-forming guanylyl cyclase-A (GC-A) receptor and cGMP-dependent kinase I (cGKI), strengthen systemic endothelial barrier properties in acute inflammation.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research